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Population pharmacokinetic modeling describes tirzepatide with a roughly 5-day half-life, supporting once-weekly dosing across the studied range, but the modeling itself is built on data from the 2.5/5/10/15 mg pen sizes
Ji L, Gao L, Xue H, et al
doi:10.3803/EnM.2024.1942 Lilly Investor Relations, News Release: Zepbound (tirzepatide) showed superior weight loss over Wegovy (semaglutide) in complete SURMOUNT-5 results published in The New England Journal of Medicine, May 11, 2025
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In a post hoc analysis of the SUMMIT trial, the decrease in estimated blood volume seen in participants treated with tirzepatide was significantly correlated with decreased blood pressure, lower microalbuminuria, improved KCCQ-CSS, and greater 6-min walking distance [85]
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