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This is evident from studies where exenatide blunted the fMRI signal in brain areas such as the amygdala, insula, hippocampus, and frontal cortex in obese individuals but not in lean individuals [16, 17]

Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

doi:10.1016/j.envpol.2023.121041 Ma Y, Zang E, Liu Y, et al

GPCRs transmit extracellular signals via coupling to heterotrimeric G proteins and interactions with -arrestins, leading to activation of various intracellular signalling cascades (15)

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