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Slowed digestion is the main cause Ozempic slows down how quickly food moves through your digestive system, which can cause constipation, says Candice Sapp, RD

A2015 study found that obese people were also likely to have thiamine deficiencies, and thiamine helps to regulate appetite

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Third, oral semaglutide (Wegovy pill, $149/mo at Walgreens) entered US distribution in late 2025, giving needle-averse patients a brand-name option for the first time